Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas.

ABSTRACT:

Objective

Differences in gastric cancer (GC) clinical outcomes between patients in Asian and non-Asian countries has been historically attributed to variability in clinical management. However, recent international Phase III trials suggest that even with standardised treatments, GC outcomes differ by geography. Here, we investigated gene expression differences between Asian and non-Asian GCs, and if these molecular differences might influence clinical outcome.

Design

We compared gene expression profiles of 1016 GCs from six Asian and three non-Asian GC cohorts, using a two-stage meta-analysis design and a novel biostatistical method (RUV-4) to adjust for technical variation between cohorts. We further validated our findings by computerised immunohistochemical analysis on two

SUBMITTER: Lin SJ 

PROVIDER: S-EPMC4680172 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature