Neural respiratory drive predicts clinical deterioration and safe discharge in exacerbations of COPD.

ABSTRACT:

Rationale

Hospitalised patients with acute exacerbation of COPD may deteriorate despite treatment, with early readmission being common.

Objectives

To investigate whether neural respiratory drive, measured using second intercostal space parasternal muscle electromyography (EMGpara), would identify worsening dyspnoea and physician-defined inpatient clinical deterioration, and predict early readmission.

Methods

Patients admitted to a single-site university hospital with exacerbation of COPD were enrolled. Spirometry, inspiratory capacity (IC), EMGpara, routine physiological parameters, modified early warning score (MEWS), modified Borg scale for dyspnoea and physician-defined episodes of deterioration were recorded daily until discharge. Readmissions at 14 and 28 days po

SUBMITTER: Suh ES 

PROVIDER: S-EPMC4680187 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature