TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice.

ABSTRACT:

Objective

To assess a new adenovirus-based immunotherapy as a novel treatment approach to chronic hepatitis B (CHB).

Methods

TG1050 is a non-replicative adenovirus serotype 5 encoding a unique large fusion protein composed of a truncated HBV Core, a modified HBV Polymerase and two HBV Envelope domains. We used a recently described HBV-persistent mouse model based on a recombinant adenovirus-associated virus encoding an over length genome of HBV that induces the chronic production of HBsAg, HBeAg and infectious HBV particles to assess the ability of TG1050 to induce functional T cells in face of a chronic status.

Results

In in vitro studies, TG1050 was shown to express the expected large polyprotein together with a dominant, smaller by-product. Following a single admin

SUBMITTER: Martin P 

PROVIDER: S-EPMC4680198 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature