Associations of interleukin-1 gene cluster polymorphisms with C-reactive protein concentration and lung function decline in smoking-induced chronic obstructive pulmonary disease.

ABSTRACT:

Objective

We reported association of haplotypes formed by IL-1b (IL1B)-511C/T (rs16944) and a variable number of tandem repeats (rs2234663) in intron 3 of IL-1 receptor antagonist (IL1RN) with rate of lung function decline in smoking-induced COPD. The aim of current study was to further investigate this association.

Methods

We genotyped an additional 19 polymorphisms in IL1 cluster (including IL1A, IL1B and IL1RN) in non-Hispanic whites who had the fastest (n = 268) and the slowest (n = 292) decline of FEV1% predicted in the same study. We also analyzed the association of all 21 polymorphisms with serum CRP levels.

Results

None of 21 polymorphisms showed significant association with rate of decline of lung function or CRP levels after adjusting for multiple comparison

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4680456 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature