Association between microRNA polymorphisms and papillary thyroid cancer susceptibility.

ABSTRACT:

Objectives

Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer, which accounts for 80-90% of all thyroid cancer cases. Though the pathological mechanism hasn't been fully understood, it is reported that both environmental and genetic factor may contribute to the PTC susceptibility. MicroRNAs (miRNAs) are small non-coding RNA molecules which function as the suppressors to participate in a variety of biological processes. Accumulating evidence suggests that polymorphisms of miRNAs were associated with the tumorigenesis of various cancers, including PTC. In this article, we focus on the association between four common microRNA polymorphisms (miR-146a, miR-608, miR-933, and miR-149) and PTC risk in a Han Chinese population.

Methods

In this case-control st

SUBMITTER: Dong G 

PROVIDER: S-EPMC4680501 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature