The investigation of foxe1 variations in papillary thyroid carcinoma.

ABSTRACT:

Background

Recent reports indicated that incidence of thyroid carcinoma is increasing throughout the worldwide. The aim of our study was to determine a possible relationship between Forkhead box E1 (FOXE1) gene variants and histopathological features of papillary thyroid carcinoma.

Methods

FOXE1 gene variations; rs894673, rs1867277 and rs3758249 were analyzed in 57 Papillary thyroid carcinoma patients and 51 age matched healthy control subjects. Restriction fragment length polymorphism (RFLP) technique was used to specifically detect the variations.

Results

There was a significant difference in the distribution of rs894673 genotypes in Papillary thyroid carcinoma cases (P=0.01). AA genotype presence of rs1867277 was more significantly associated with several histopath

SUBMITTER: Somuncu E 

PROVIDER: S-EPMC4680502 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature