The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.

ABSTRACT:

Background

Posttranslational modifications (PTMs) such as acetylation, detyrosination, and polyglutamylation have long been considered markers of stable microtubules and have recently been proposed to guide molecular motors to specific subcellular destinations. Microtubules can be deglutamylated by the cytosolic carboxypeptidase CCP1. Loss of CCP1 in mice causes cerebellar Purkinje cell degeneration. Cilia, which are conserved organelles that play important diverse roles in animal development and sensation, contain axonemes comprising microtubules that are especially prone to PTMs.

Results

Here, we report that a CCP1 homolog, CCPP-1, regulates the ciliary localization of the kinesin-3 KLP-6 and the polycystin PKD-2 in male-specific sensory neurons in C. elegans. In male-spec

SUBMITTER: O'Hagan R 

PROVIDER: S-EPMC4680987 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature