Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.

ABSTRACT: In recent years, several associations between common chronic human disorders and altered gut microbiome composition and function have been reported. In most of these reports, treatment regimens were not controlled for and conclusions could thus be confounded by the effects of various drugs on the microbiota, which may obscure microbial causes, protective factors or diagnostically relevant signals. Our study addresses disease and drug signatures in the human gut microbiome of type 2 diabetes mellitus (T2D). Two previous quantitative gut metagenomics studies of T2D patients that were unstratified for treatment yielded divergent conclusions regarding its associated gut microbial dysbiosis. Here we show, using 784 available human gut metagenomes, how antidiabetic medication confounds these res

SUBMITTER: Forslund K 

PROVIDER: S-EPMC4681099 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature