Disease association and inter-connectivity analysis of human brain specific co-expressed functional modules.

ABSTRACT:

Background

In the recent studies, it is suggested that the analysis of transcriptomic change of functional modules instead of individual genes would be more effective for system-wide identification of cellular functions. This could also provide a new possibility for the better understanding of difference between human and chimpanzee.

Results

In this study, we analyzed to find molecular characteristics of human brain functions from the difference of transcriptome between human and chimpanzee's brain using the functional module-centric co-expression analysis. We performed analysis of brain disease association and systems-level connectivity of species-specific co-expressed functional modules.

Conclusions

Throughout the analyses, we found human-specific functional modules

SUBMITTER: Oh K 

PROVIDER: S-EPMC4681143 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature