Patient-specific Immune States before Surgery Are Strong Correlates of Surgical Recovery.

ABSTRACT:

Background

Recovery after surgery is highly variable. Risk-stratifying patients based on their predicted recovery profile will afford individualized perioperative management strategies. Recently, application of mass cytometry in patients undergoing hip arthroplasty revealed strong immune correlates of surgical recovery in blood samples collected shortly after surgery. However, the ability to interrogate a patient's immune state before surgery and predict recovery is highly desirable in perioperative medicine.

Methods

To evaluate a patient's presurgical immune state, cell-type-specific intracellular signaling responses to ex vivo ligands (lipopolysaccharide, interleukin [IL]-6, IL-10, and IL-2/granulocyte macrophage colony-stimulating factor) were quantified by mass cytometry

SUBMITTER: Fragiadakis GK 

PROVIDER: S-EPMC4681408 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature