Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.

ABSTRACT: We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.

SUBMITTER: Etxeberria A 

PROVIDER: S-EPMC4681435 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature