Ex Vivo Modeling of Multidomain Peptide Hydrogels with Intact Dental Pulp.

ABSTRACT: Preservation of a vital dental pulp is a central goal of restorative dentistry. Currently, there is significant interest in the development of tissue engineering scaffolds that can serve as biocompatible and bioactive pulp-capping materials, driving dentin bridge formation without causing cytotoxic effects. Our earlier in vitro studies described the biocompatibility of multidomain peptide (MDP) hydrogel scaffolds with dental pulp-derived cells but were limited in their ability to model contact with intact 3-dimensional pulp tissues. Here, we utilize an established ex vivo mandible organ culture model to model these complex interactions. MDP hydrogel scaffolds were injected either at the interface of the odontoblasts and the dentin or into the pulp core of mandible slices and subsequently c

SUBMITTER: Moore AN 

PROVIDER: S-EPMC4681475 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature