Auditory Cortical Plasticity Drives Training-Induced Cognitive Changes in Schizophrenia.

ABSTRACT: Schizophrenia is characterized by dysfunction in basic auditory processing, as well as higher-order operations of verbal learning and executive functions. We investigated whether targeted cognitive training of auditory processing improves neural responses to speech stimuli, and how these changes relate to higher-order cognitive functions. Patients with schizophrenia performed an auditory syllable identification task during magnetoencephalography before and after 50 hours of either targeted cognitive training or a computer games control. Healthy comparison subjects were assessed at baseline and after a 10 week no-contact interval. Prior to training, patients (N = 34) showed reduced M100 response in primary auditory cortex relative to healthy participants (N = 13). At reassessment, only the

SUBMITTER: Dale CL 

PROVIDER: S-EPMC4681549 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature