Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis.

ABSTRACT:

Background

There are currently no biomarkers for early breast cancer patient populations at risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical interest.

Methods

A de novo unbiased screening approach based on selection of highly bone metastatic breast cancer cells in vivo was used to determine copy number aberrations (CNAs) associated with bone metastasis. The CNAs associated with bone metastasis were examined in independent primary breast cancer datasets with annotated clinical follow-up. The MAF gene encoded within the CNA associated with bone metastasis was subjected to gain and loss of function validation in breast cancer cells (MCF7, T47D, ZR-75, and 4T1), its downstream mechanism validated, and tested in clinical samples. A mult

SUBMITTER: Pavlovic M 

PROVIDER: S-EPMC4681582 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature