Mefloquine in the nucleus accumbens promotes social avoidance and anxiety-like behavior in mice.

ABSTRACT: Mefloquine continues to be a key drug used for malaria chemoprophylaxis and treatment, despite reports of adverse events like depression and anxiety. It is unknown how mefloquine acts within the central nervous system to cause depression and anxiety or why some individuals are more vulnerable. We show that intraperitoneal injection of mefloquine in mice, when coupled to subthreshold social defeat stress, is sufficient to produce depression-like social avoidance behavior. Direct infusion of mefloquine into the nucleus accumbens (NAc), a key brain reward region, increased stress-induced social avoidance and anxiety behavior. In contrast, infusion into the ventral hippocampus had no effect. Whole cell recordings from NAc medium spiny neurons indicated that mefloquine application increases the

SUBMITTER: Heshmati M 

PROVIDER: S-EPMC4681593 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature