Neuraxial block and postoperative epidural analgesia: effects on outcomes in the POISE-2 trial†.

ABSTRACT:

Background

We assessed associations between intraoperative neuraxial block and postoperative epidural analgesia, and a composite primary outcome of death or non-fatal myocardial infarction, at 30 days post-randomization in POISE-2 Trial subjects.

Methods

10 010 high-risk noncardiac surgical patients were randomized aspirin or placebo and clonidine or placebo. Neuraxial block was defined as intraoperative spinal anaesthesia, or thoracic or lumbar epidural anaesthesia. Postoperative epidural analgesia was defined as postoperative epidural local anaesthetic and/or opioid administration. We used logistic regression with weighting using estimated propensity scores.

Results

Neuraxial block was not associated with the primary outcome [7.5% vs 6.5%; odds ratio (OR), 0.89; 95%

SUBMITTER: Leslie K 

PROVIDER: S-EPMC4681616 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature