Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up.

ABSTRACT:

Purpose

Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients.

Methods

T1- and diffusion-weighted MR images were obtained for schizophrenia (n=30) and matched healthy control participants (n=30). Negative symptoms and functional outcome were assessed at baseline and 6-month follow-up. Cortical thickness and tract-wise fractional anisotropy (FA) were compared between groups. To assess relationships of neuroimaging measures with functional outcome, principal component analysis (PCA) was performed on tract-wise FA values and components were

SUBMITTER: Behdinan T 

PROVIDER: S-EPMC4681643 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature