Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.

ABSTRACT:

Introduction

African-American (AA) individuals have a higher risk for late-onset Alzheimer's disease (LOAD) than Americans of primarily European ancestry (EA). Recently, the largest genome-wide association study in AAs to date confirmed that six of the Alzheimer's disease (AD)-related genetic variants originally discovered in EA cohorts are also risk variants in AA; however, the risk attributable to many of the loci (e.g., APOE, ABCA7) differed substantially from previous studies in EA. There likely are risk variants of higher frequency in AAs that have not been discovered.

Methods

We performed a comprehensive analysis of genetically determined local and global ancestry in AAs with regard to LOAD status.

Results

Compared to controls, LOAD cases showed higher levels of

SUBMITTER: Hohman TJ 

PROVIDER: S-EPMC4681680 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature