Immune system transcriptome in gingival tissues of young nonhuman primates.

ABSTRACT:

Background and objective

Young/adolescent humans harbor many microorganisms associated with periodontal disease in adults and show substantial gingival inflammatory responses. However, younger individuals do not demonstrate the soft- and hard-tissue destruction that hallmark periodontitis.

Material and methods

This study evaluated responses to the oral microbial ecology in gingival tissues from clinically healthy young Macaca mulatta (< 3 years of age) compared with older animals (5-23 years of age). RNA was isolated from the tissues and analyzed for the transcriptome using the Rhesus Macaque GeneChip (Affymetrix).

Results

Global transcriptional profiling of four age groups revealed a subset of 159 genes that were differentially expressed across at least one of the ag

SUBMITTER: Gonzalez OA 

PROVIDER: S-EPMC4681702 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature