Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering.

ABSTRACT: Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high extrusion and infection rates. Matching mechanical properties of synthetic materials to the native tissue they are replacing has shown to be important in the biocompatibility of implants. To date the mechanical properties of the human nasal cartilages has not been studied in depth to be able to create tissue-engineered replacements with similar mechanical properties to native tissue. The young's modulus was characterized in compression on fresh-frozen human cadaveric septal, alar, and lateral cartilage. Due to the functional differences experie

SUBMITTER: Griffin MF 

PROVIDER: S-EPMC4681753 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature