Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation.

ABSTRACT: Patients with chronic inflammation are often associated with the emergence of depression symptoms, while diagnosed depressed patients show increased levels of circulating cytokines. Further studies revealed the activation of the brain immune cell microglia in depressed patients with a greater magnitude in individuals that committed suicide, indicating a crucial role for neuroinflammation in depression brain pathogenesis. Rapid advances in the understanding of microglial and astrocytic neurobiology were obtained in the past 15-20 years. Indeed, recent data reveal that microglia play an important role in managing neuronal cell death, neurogenesis, and synaptic interactions, besides their involvement in immune-response generating cytokines. The communication between microglia and neurons is e

SUBMITTER: Brites D 

PROVIDER: S-EPMC4681811 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature