Left-right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis.

ABSTRACT: Morphogenetic epithelial movement occurs during embryogenesis and drives complex tissue formation. However, how epithelial cells coordinate their unidirectional movement while maintaining epithelial integrity is unclear. Here we propose a novel mechanism for collective epithelial cell movement based on Drosophila genitalia rotation, in which epithelial tissue rotates clockwise around the genitalia. We found that this cell movement occurs autonomously and requires myosin II. The moving cells exhibit repeated left-right-biased junction remodelling, while maintaining adhesion with their neighbours, in association with a polarized myosin II distribution. Reducing myosinID, known to cause counter-clockwise epithelial-tissue movement, reverses the myosin II distribution. Numerical simulations re

SUBMITTER: Sato K 

PROVIDER: S-EPMC4682055 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature