Expression of mouse CD47 on human cancer cells profoundly increases tumor metastasis in murine models.

ABSTRACT:

Background

Many commonly used xenograft tumor models do not spontaneously metastasize to distant organs following subcutaneous or orthotopic implantation, limiting their usefulness in preclinical studies. It is generally believed that natural killer cells are the key component of the innate immune system in determining tumor metastatic potential in xenograft models. However, recent studies suggest that macrophages may play an important role, as resident macrophages can eliminate the invading tumor cells if they do not express adequate levels of the CD47 molecule.

Methods

We investigated the effect of overexpressing murine CD47 (mCD47) in PC-3 cells, a commonly used human prostate cancer line, on the metastatic potential in three mouse strains with different genetic backgroun

SUBMITTER: Rivera A 

PROVIDER: S-EPMC4682254 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature