Longitudinal changes in peripapillary atrophy in the ocular hypertension treatment study: a case-control assessment.

ABSTRACT:

Purpose

To explore the association between peripapillary atrophy (PPA) area and conversion from ocular hypertension (OHT) to glaucoma.

Design

Prospective, longitudinal cohort study of cases and controls.

Participants

We included 279 age-matched and follow-up time-matched eyes with OHT that converted to glaucoma and 279 eyes with OHT that did not convert to glaucoma.

Methods

Initial and last acceptable optic disc photos were analyzed. Disc, α-zone, and β-zone PPA were traced independently by 2 trained readers and their areas were measured with Photoshop. The α-zone and β-zone areas were expressed as a percentage of optic disc area.

Main outcome measures

α-Zone and β-zone PPA size over time.

Results

Intraclass correlation coefficients (ICCs) demonst

SUBMITTER: Savatovsky E 

PROVIDER: S-EPMC4682350 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature