SCMMTP: identifying and characterizing membrane transport proteins using propensity scores of dipeptides.

ABSTRACT:

Background

Identifying putative membrane transport proteins (MTPs) and understanding the transport mechanisms involved remain important challenges for the advancement of structural and functional genomics. However, the transporter characters are mainly acquired from MTP crystal structures which are hard to crystalize. Therefore, it is desirable to develop bioinformatics tools for the effective large-scale analysis of available sequences to identify novel transporters and characterize such transporters.

Results

This work proposes a novel method (SCMMTP) based on the scoring card method (SCM) using dipeptide composition to identify and characterize MTPs from an existing dataset containing 900 MTPs and 660 non-MTPs which are separated into a training dataset consisting 1,380 pr

SUBMITTER: Liou YF 

PROVIDER: S-EPMC4682407 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature