A theoretical investigation of DNA dynamics and desolvation kinetics for zinc finger proteinZif268.

ABSTRACT:

Background

Transcription factors, regulating the expression inventory of a cell, interact with its respective DNA subjugated by a specific recognition pattern, which if well exploited may ensure targeted genome engineering. The mostly widely studied transcription factors are zinc finger proteins that bind to its target DNA via direct and indirect recognition levels at the interaction interface. Exploiting the binding specificity and affinity of the interaction between the zinc fingers and the respective DNA can help in generating engineered zinc fingers for therapeutic applications. Experimental evidences lucidly substantiate the effect of indirect interaction like DNA deformation and desolvation kinetics, in empowering ZFPs to accomplish partial sequence specificity functioning ar

SUBMITTER: Dutta S 

PROVIDER: S-EPMC4682422 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature