Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.

ABSTRACT: There is a well-described association between infantile epilepsy and pervasive cognitive and behavioral deficits, including a high incidence of autism spectrum disorders. Despite the robustness of the relationship between early-life seizures and the development of autism, the pathophysiological mechanism by which this occurs has not been explored. As a result of increasing evidence that autism is a disorder of brain connectivity we hypothesized that early-life seizures would interrupt normal brain connectivity during brain maturation and result in an autistic phenotype. Normal rat pups underwent recurrent flurothyl-induced seizures from postnatal (P)days 5-14 and then tested, along with controls, for developmental alterations of development brain oscillatory activity from P18-P25. Specific

SUBMITTER: Holmes GL 

PROVIDER: S-EPMC4682568 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature