Antibacterial Peptide-Based Gel for Prevention of Medical Implanted-Device Infection.

ABSTRACT: Implanted medical devices are prone to infection. Designing new strategies to reduce infection and implant rejection are an important challenge for modern medicine. To this end, in the last few years many hydrogels have been designed as matrices for antimicrobial molecules destined to fight frequent infection found in moist environments like the oral cavity. In this study, two types of original hydrogels containing the antimicrobial peptide Cateslytin have been designed. The first hydrogel is based on alginate modified with catechol moieties (AC gel). The choice of these catechol functional groups which derive from mussel's catechol originates from their strong adhesion properties on various surfaces. The second type of gel we tested is a mixture of alginate catechol and thiol-terminated P

SUBMITTER: Mateescu M 

PROVIDER: S-EPMC4682826 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature