Immortalized Human Schwann Cell Lines Derived From Tumors of Schwannomatosis Patients.

ABSTRACT: Schwannomatosis, a rare form of neurofibromatosis, is characterized predominantly by multiple, often painful, schwannomas throughout the peripheral nervous system. The current standard of care for schwannomatosis is surgical resection. A major obstacle to schwannomatosis research is the lack of robust tumor cell lines. There is a great need for mechanistic and drug discovery studies of schwannomatosis, yet appropriate tools are not currently available. Schwannomatosis tumors are difficult to grow in culture as they survive only a few passages before senescence. Our lab has extensive experience in establishing primary and immortalized human Schwann cell cultures from normal tissue that retain their phenotypes after immortalization. Therefore we took on the challenge of creating immortalized

SUBMITTER: Ostrow KL 

PROVIDER: S-EPMC4682832 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature