Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder.

ABSTRACT: Alack of inhibition control has been found in subjects with conduct disorder (CD), but the underlying neuropathophysiology remains poorly understood. The current study investigated the different mechanism of inhibition control in adolescent-onset CD males (n = 29) and well-matched healthy controls (HCs) (n = 40) when performing a GoStop task by functional magnetic resonance images. Effective connectivity (EC) within the inhibition control network was analyzed using a stochastic dynamic causality model. We found that EC within the inhibition control network was significantly different in the CD group when compared to the HCs. Exploratory relationship analysis revealed significant negative associations between EC between the IFG and striatum and behavioral scale scores in the CD group. These

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4682835 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature