CD33 modulates TREM2: convergence of Alzheimer loci.

ABSTRACT: We used a protein quantitative trait analysis in monocytes from 226 individuals to evaluate cross-talk between Alzheimer loci. The NME8 locus influenced PTK2B and the CD33 risk allele led to greater TREM2 expression. There was also a decreased TREM1/TREM2 ratio with a TREM1 risk allele, decreased TREM2 expression with CD33 suppression and elevated cortical TREM2 mRNA expression with amyloid pathology.

SUBMITTER: Chan G 

PROVIDER: S-EPMC4682915 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature