Dynamic Network Drivers of Seizure Generation, Propagation and Termination in Human Neocortical Epilepsy.

ABSTRACT: The epileptic network is characterized by pathologic, seizure-generating 'foci' embedded in a web of structural and functional connections. Clinically, seizure foci are considered optimal targets for surgery. However, poor surgical outcome suggests a complex relationship between foci and the surrounding network that drives seizure dynamics. We developed a novel technique to objectively track seizure states from dynamic functional networks constructed from intracranial recordings. Each dynamical state captures unique patterns of network connections that indicate synchronized and desynchronized hubs of neural populations. Our approach suggests that seizures are generated when synchronous relationships near foci work in tandem with rapidly changing desynchronous relationships from the surroun

SUBMITTER: Khambhati AN 

PROVIDER: S-EPMC4682976 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature