A Spatially Continuous Model of Carbohydrate Digestion and Transport Processes in the Colon.

ABSTRACT: A spatially continuous mathematical model of transport processes, anaerobic digestion and microbial complexity as would be expected in the human colon is presented. The model is a system of first-order partial differential equations with context determined number of dependent variables, and stiff, non-linear source terms. Numerical simulation of the model is used to elucidate information about the colon-microbiota complex. It is found that the composition of materials on outflow of the model does not well-describe the composition of material in other model locations, and inferences using outflow data varies according to model reactor representation. Additionally, increased microbial complexity allows the total microbial community to withstand major system perturbations in diet and communit

SUBMITTER: Moorthy AS 

PROVIDER: S-EPMC4683063 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature