MicroRNA Function Is Limited to Cytokine Control in the Acute Response to Virus Infection.

ABSTRACT: With the capacity to fine-tune protein expression via sequence-specific interactions, microRNAs (miRNAs) help regulate cell maintenance and differentiation. While some studies have also implicated miRNAs as regulators of the antiviral response, others have found that the RISC complex that facilitates miRNA-mediated silencing is rendered nonfunctional during cellular stress, including virus infection. To determine the global role of miRNAs in the cellular response to virus infection, we generated a vector that rapidly eliminates total cellular miRNA populations in terminally differentiated primary cultures. Loss of miRNAs has a negligible impact on both innate sensing of and immediate response to acute viral infection. In contrast, miRNA depletion specifically enhances cytokine expression,

SUBMITTER: Aguado LC 

PROVIDER: S-EPMC4683400 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature