Phylogenomic analyses reveal a molecular signature linked to subterranean adaptation in rodents.

ABSTRACT:

Background

Genome-wide signatures of convergent evolution are widely expected but rarely revealed in animals. Subterranean rodent genome and transcriptome data produced by next-generation sequencing facilitate the use of phylogenetic methods to infer non-synonymous and synonymous substitution rates within coding regions, which can reveal changes at the molecular level that are correlated with the dramatic shift from a terrestrial to subterranean habitat.

Results

Our study used previously sequenced genome or transcriptome data of two subterranean rodents, the blind mole rat and naked mole rat, and their terrestrial relatives, the mouse and guinea pig, to investigate the genetic basis of rodent subterranean adaptation. An analysis of 4996 orthologous genes revealed that the su

SUBMITTER: Du K 

PROVIDER: S-EPMC4683706 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature