Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study.

ABSTRACT:

Background

Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.

Methods

In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score--GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age(2), sex, MI (yes/no), and population substructure.

Results

Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allel

SUBMITTER: Ahmad S 

PROVIDER: S-EPMC4683724 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature