The transcriptional profile of coronary arteritis in Kawasaki disease.

ABSTRACT:

Background

Kawasaki Disease (KD) can cause potentially life-threatening coronary arteritis in young children, and has a likely infectious etiology. Transcriptome profiling is a powerful approach to investigate gene expression in diseased tissues. RNA sequencing of KD coronary arteries could elucidate the etiology and the host response, with the potential to improve KD diagnosis and/or treatment.

Methods

Deep RNA sequencing was performed on KD (n = 8) and childhood control (n = 7) coronary artery tissues, revealing 1074 differentially expressed mRNAs. Non-human RNA sequences were subjected to a microbial discovery bioinformatics platform, and microbial sequences were analyzed by Metastats for association with KD.

Results

T lymphocyte activation, antigen presentation, i

SUBMITTER: Rowley AH 

PROVIDER: S-EPMC4683744 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature