The value of core lab stress echocardiography interpretations: observations from the ISCHEMIA Trial.

ABSTRACT:

Background

Stress echocardiography (SE) is dependent on subjective interpretations. As a prelude to the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) Trial, potential sites were required to submit two SE, one with moderate or severe left ventricular (LV) myocardial ischemia and one with mild ischemia. We evaluated the concordance of site and core lab interpretations.

Methods

Eighty-one SE were submitted from 41 international sites. Ischemia was classified by the number of new or worsening segmental LV wall motion abnormalities (WMA): none, mild (1 or 2) or moderate or severe (3 or more) by the sites and the core lab.

Results

Core lab classified 6 SE as no ischemia, 35 mild and 40 moderate or greater. There was

SUBMITTER: Kataoka A 

PROVIDER: S-EPMC4683787 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature