The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy.

ABSTRACT:

Background

Anaplastic thyroid carcinoma is the most undifferentiated form of thyroid cancer and one of the deadliest of all adult solid malignancies. Here we report the first genomic and transcriptomic profile of anaplastic thyroid cancer including those of several unique cell lines and outline novel potential drivers of malignancy and targets of therapy.

Methods

We describe whole genomic and transcriptomic profiles of 1 primary anaplastic thyroid tumor and 3 authenticated cell lines. Those profiles augmented by the transcriptomes of 4 additional and unique cell lines were compared to 58 pairs of papillary thyroid carcinoma and matched normal tissue transcriptomes from The Cancer Genome Atlas study.

Results

The most prevalent mutations were those of TP53 and BRAF; rep

SUBMITTER: Kasaian K 

PROVIDER: S-EPMC4683857 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature