Aspergillus nidulans protein kinase A plays an important role in cellulase production.

ABSTRACT:

Background

The production of bioethanol from lignocellulosic feedstocks is dependent on lignocellulosic biomass degradation by hydrolytic enzymes. The main component of lignocellulose is cellulose and different types of organisms are able to secrete cellulases. The filamentous fungus Aspergillus nidulans serves as a model organism to study cellulase production and the available tools allow exploring more in depth the mechanisms governing cellulase production and carbon catabolite repression.

Results

In A. nidulans, microarray data identified the cAMP-dependent protein kinase A (PkaA) as being involved in the transcriptional modulation and the production of lignocellulolytic enzymes in the presence of cellulose. Deletion of pkaA resulted in increased hydrolytic enzyme secreti

SUBMITTER: de Assis LJ 

PROVIDER: S-EPMC4683954 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature