Host microbiota modulates development of social preference in mice.

ABSTRACT:

Background

Mounting evidence indicates that the indigenous gut microbiota exerts long-lasting programming effects on brain function and behaviour.

Objective

In this study, we used the germ-free (GF) mouse model, devoid of any microbiota throughout development, to assess the influence of the indigenous microbiota on social preference and repetitive behaviours (e.g. self-grooming).

Methods and results

Using the three-chambered social approach task, we demonstrate that when adult GF mice were given a choice to spend time with a novel mouse or object, they spent significantly more time sniffing and interacting with the stimulus mouse compared to conventionally raised mice (specific pathogen-free, SPF). Time spent in repetitive self-grooming behaviour, however, did not dif

SUBMITTER: Arentsen T 

PROVIDER: S-EPMC4683992 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature