Neuropsychiatry and White Matter Microstructure in Huntington's Disease.

ABSTRACT:

Background

Neuropsychiatric symptoms in Huntington's disease (HD) are often evident prior to clinical diagnosis. Apathy is highly correlated with disease progression, while depression and irritability occur at different stages of the disease, both before and after clinical onset. Little is understood about the neural bases of these neuropsychiatric symptoms and to what extent those neural bases are analogous to neuropsychiatric disorders in the general population.

Objective

We used Diffusion Tensor Imaging (DTI) to investigate structural connectivity between brain regions and any putative microstructural changes associated with depression, apathy and irritability in HD.

Methods

DTI data were collected from 39 premanifest and 45 early-HD participants in the Track-HD st

SUBMITTER: Gregory S 

PROVIDER: S-EPMC4684097 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature