Ontology highlight
ABSTRACT:
SUBMITTER: Vermulst M
PROVIDER: S-EPMC4684168 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Nature communications 20150825
Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitizes them to the expression of genes that are associated with protein-folding diseases in humans; thus, transcription errors represent a new molecular mechanism by which cells can acqu ...[more]