A Selective V(1A) Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock.

ABSTRACT:

Objective

Selective vasopressin V(1A) receptor agonists may have advantages over arginine vasopressin in the treatment of septic shock. We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.

Design

Randomized animal study.

Setting

University hospital animal research laboratory.

Subjects

Forty-six adult female sheep.

Interventions

Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases. Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or n

SUBMITTER: He X 

PROVIDER: S-EPMC4684247 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature