Contribution of Peptide Backbone to Anti-Citrullinated Peptide Antibody Reactivity.

ABSTRACT: Rheumatoid arthritis (RA) is one of the most common autoimmune diseases, affecting approximately 1-2% of the world population. One of the characteristic features of RA is the presence of autoantibodies. Especially the highly specific anti-citrullinated peptide antibodies (ACPAs), which have been found in up to 70% of RA patients' sera, have received much attention. Several citrullinated proteins are associated with RA, suggesting that ACPAs may react with different sequence patterns, separating them from traditional antibodies, whose reactivity usually is specific towards a single target. As ACPAs have been suggested to be involved in the development of RA, knowledge about these antibodies may be crucial. In this study, we examined the influence of peptide backbone for ACPA reactivity in i

SUBMITTER: Trier NH 

PROVIDER: S-EPMC4684344 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature