Brief cognitive training interventions in young adulthood promote long-term resilience to drug-seeking behavior.

ABSTRACT: Environmental stress and deprivation increase vulnerability to substance use disorders in humans and promote drug-seeking behavior in animal models. In contrast, experiences of mastery and stability may shape neural circuitry in ways that build resilience to future challenges. Cognitive training offers a potential intervention for reducing vulnerability in the face of environmental stress or deprivation. Here, we test the hypothesis that brief cognitive training can promote long-term resilience to one measure of drug-seeking behavior, cocaine conditioned place preference (CPP), in mice. In young adulthood, mice underwent cognitive training, received rewards while exploring a training arena (i.e. yoked control), or remained in their home cages. Beginning 4 weeks after cessation of training,

SUBMITTER: Boivin JR 

PROVIDER: S-EPMC4684575 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature