Ontology highlight
ABSTRACT:
SUBMITTER: Tateishi K
PROVIDER: S-EPMC4684594 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20151201 6
Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG). Here, we found that 2-HG depletion did not inhibit growth of several IDH1 mutant solid cancer types. To identify other metabolic therapeutic targets, we systematically profiled metabolites in endogenous IDH1 mutant cancer cells after mutant IDH1 inhibition and discovered a profound vulnerability to depletion of the coenzyme NAD+. Mutant IDH1 l ...[more]