The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.

ABSTRACT: Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan

SUBMITTER: Valenzano DR 

PROVIDER: S-EPMC4684691 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature