Burden of transmitted multidrug resistance in epidemics of tuberculosis: a transmission modelling analysis.

ABSTRACT:

Background

Multidrug-resistant (MDR) tuberculosis can be acquired through de-novo mutation during tuberculosis treatment or through transmission from other individuals with active MDR tuberculosis. Understanding the balance between these two mechanisms is essential when allocating resources for MDR tuberculosis. We aimed to create a dynamic transmission model of an MDR tuberculosis epidemic to estimate the contributions of treatment-related acquisition and person-to-person transmission of resistance to incident MDR tuberculosis cases.

Methods

In this modelling analysis, we constructed a dynamic transmission model of an MDR tuberculosis epidemic, allowing for both treatment-related acquisition and person-to-person transmission of resistance. We used national tuberculosis noti

SUBMITTER: Kendall EA 

PROVIDER: S-EPMC4684734 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature