Hypothyroxinemia During Gestation and Offspring Schizophrenia in a National Birth Cohort.

ABSTRACT:

Background

Evidence from animal and human studies indicates that thyroid hormone deficiency during early gestation alters brain development. As schizophrenia is associated with prenatal brain insults and premorbid cognitive deficits, we tested the a priori hypothesis that serologically defined maternal thyroid deficiency during early gestation to mid-gestation is associated with schizophrenia in offspring.

Methods

The investigation is based on the Finnish Prenatal Study of Schizophrenia, a nested case-control study that included archived maternal sera from virtually all pregnancies since 1983 (N = >1 million). We identified all offspring in the cohort with a diagnosis of schizophrenia based on the national inpatient and outpatient register and matched them on sex, date of bi

SUBMITTER: Gyllenberg D 

PROVIDER: S-EPMC4684794 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature